A Cyclodiaryliodonium NOX Inhibitor for the Treatment of Pancreatic Cancer via Enzyme‐Activatable Targeted Delivery by Sulfated Glycosaminoglycan Derivatives (Adv. Healthcare Mater. 17/2023)
نویسندگان
چکیده
Nanoparticle-Drug Conjugates To combat pancreatic cancer with a dismal prognosis, self-assembled nanoparticle-drug conjugate is synthesized in article 2203011 by Peng Huang, Shijun Wen, Jiang Yang, and co-workers. Based on chemically-modified sulfated glycosaminoglycan derivatives, (NDC) efficiently encapsulates cyclodiaryliodonium NOX inhibitor from pooled screening, enabling hyaluronidase-activatable release, facilitates CD44-targeted cellular trafficking to elicit anti-cancer efficacy good safety profile.
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ژورنال
عنوان ژورنال: Advanced Healthcare Materials
سال: 2023
ISSN: ['2192-2640', '2192-2659']
DOI: https://doi.org/10.1002/adhm.202370091